Gliclazide is a medication used to treat type 2 diabetes by helping the body produce less glucose, especially during meals. When taken, it lowers blood sugar levels by stimulating the release of insulin from the pancreas, making it a sulfonylurea drug. Compared to other sulfonylureas, gliclazide is a second-generation selective drug for pancreatic beta cells, with a longer duration of action and less effect on thyroid and renal cells. Once ingested, it is hydrolyzed into gliclazide monohydrochloride in the intestine, absorbed into the bloodstream, and cleared from the blood by the kidneys. Gliclazide binds to sulfonylurea receptors on the beta cells, stimulating insulin release and decreasing blood glucose levels, while also inducing a minor release of insulin directly affecting the beta cells, decreasing glucose production in the liver.
- Treatment for type 2 diabetes mellitus can include medications like gliclazide, which is a second-generation sulfonylurea hypoglycemic drug.
- Gliclazide aids in lowering blood glucose levels in patients with diabetes mellitus.
- This drug stimulates insulin secretion from the pancreas, which aids the process of blood glucose control.
- It is usually prescribed to patients when diet and exercise alone or metformin has not been enough to control blood glucose levels.
Composition
Each controlled release tablet contains:
- Gliclazide: 60 mg
Dosage
- As recommended by a registered medical practitioner.
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