RyzodegR® is a soluble insulin product consisting of the basal insulin degludec and the rapid-acting prandial insulin apart. The potency of insulin analogues, including RyzodegR®, is expressed in units. One (1) unit of this insulin corresponds to 1 international unit of human insulin, 1 unit of insulin glargine, 1 unit of insulin detemir or 1 unit of biphasic insulin as part. RyzodegR is to be dosed in accordance with the individual patient's needs. Dose-adjustments are recommended to be based on fasting plasma glucose measurements.
Adjustment of dose may be necessary if patients undertake increased physical activity, change their usual diet or during concomitant illness. Patients with type 2 diabetes mellitus RyzodegR can be administered once or twice daily with the main meal(s) alone, in combination with oral antidiabetic medicinal products, and in combination with bolus insulin. When using RyzodegR once-daily, changing to twice daily should be considered when higher doses are needed, e.g. to avoid hypoglycemia. Split the dose based on individual patient's needs and administer with main meals.
Composition
1 ml solution contains 100 units insulin degludec/insulin aspart* in the ratio 70/30 (equivalent to 2.56 mg insulin degludec and 1.05 mg insulin aspart).
One cartridge contains 300 units of insulin degludec/ insulin aspart in 3 ml solution.
*Produced in Saccharomyces cerevisiae by recombinant DNA technology.
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