Sulfasalazine is a prodrug that, upon metabolism in the colon, breaks down into sulfapyridine and 5-aminosalicylic acid (5-ASA). Its mechanism of action involves both anti-inflammatory and immunomodulatory effects. The 5-ASA component reduces inflammation by inhibiting the production of pro-inflammatory cytokines and blocking the cyclooxygenase (COX) and lipoxygenase pathways, which decreases the synthesis of prostaglandins and leukotrienes. Additionally, it scavenges free radicals that contribute to inflammation.
- Sulfasalazine is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed.
Composition
Each delayed release tablet contains:
- Sulfasalazine: 500 mg
Dosage
- As recommended by a registered medical practitioner.
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